Pendant ce temps…
Posté par abc10 le 16 juillet 2023
Ce monde est dingue ,les dirigeants qui nous gouvernent sont de dangereux irresponsables,pendant que le monde-village est au bord de l’asphyxie , les dérèglements climatiques sont annonciateurs du pire : la fin de la vie sur terre ..et pendant ce temps , comme disait Jacques Chirac ,que Dieu aie son âme : notre maison commune brûle et nous regardons ailleurs.
10 millions d’hectares de forêt sont partis en fumée ces derniers jours au Canada , l’équivalent de la superficie du Portugal…pendant ce temps les dirigeants occidentaux dont le premier ministre canadien , est parti à Vilnius avec ses compères de l’OTAN , tout sourire , bomber le torse , tout fière pour prendre des selfies avec Zelensky et lui promettre des armes toujours plus sophistiquées : les vendeurs d’armes se frottent les mains ,les foyers de tention sont partout ,les budgets militaires explosent , les experts militaires et les va-t-en guerre sont légions dans les Stream médias.
“ Ce n’est point les yeux qui sont frappés de cécité , mais ce sont plutôt les cœurs dans les poitrines qui sont aveugles ” dit le Saint Coran .
Caen-Chemin vert , le 16 juillet 2023 .
B.Zine
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Ipamorelin and sermorelin are two peptides that have gained popularity among those looking to enhance growth hormone release for reasons ranging from anti-aging
and muscle building to recovery and overall health improvement.
Although they share the common goal of stimulating growth hormone secretion, they differ in their chemical structures, mechanisms of action, dosage schedules,
and clinical applications. Understanding these
differences is essential before deciding whether to use them together or separately.
Can You Take Ipamorelin And Sermorelin Together?
The short answer is yes, many practitioners and users combine ipamorelin and sermorelin in a single protocol.
Because they act on the pituitary gland via different receptors—ipamorelin as a selective growth hormone-releasing peptide
(GHRP) that mimics ghrelin, and sermorelin as a synthetic analogue of growth
hormone-releasing hormone (GHRH)—the combination can produce a synergistic effect.
The typical protocol involves administering both peptides in the evening dianabol before and after pics bed: ipamorelin is often given first because it
has a rapid onset, followed by sermorelin after a
few minutes or with a small time interval.
Users report increased total nightly growth hormone levels and more pronounced overnight recovery.
However, combining them also raises considerations about dosage, potential
side effects, and cost. Because each peptide can elevate blood sugar, heart rate, and water retention to varying
degrees, monitoring is essential. Some protocols recommend
staggering the injections—ipamorelin once daily in the evening and
sermorelin twice daily (morning and night)—to balance peak
hormone levels without overstimulation. It’s also advisable to consult a healthcare
professional familiar with peptide therapy before starting any
combined regimen.
What Are Ipamorelin And Sermorelin?
Ipamorelin is a pentapeptide, meaning it contains five amino acids linked together.
Its sequence is Met-Glu-His-D-Ala-Lys. This structure allows ipamorelin to bind selectively
to the ghrelin receptor on pituitary cells, triggering the release of growth hormone.
Ipamorelin is known for its high selectivity; unlike other GHRPs such as GHRP-2 and GHRP-6,
it does not significantly stimulate prolactin or
cortisol secretion. This characteristic makes it a preferred choice for users seeking minimal
side effects.
Sermorelin, on the other hand, is a decapeptide that mimics the natural hormone growth hormone-releasing
hormone (GHRH). Its amino acid sequence is His-D-Lys-Glu-Pro-Ser-Thr-Arg-Leu-Asp-Lys.
When administered, sermorelin binds to GHRH receptors in the pituitary gland, stimulating endogenous growth hormone
production and release. Because it is a near-identical mimic of the natural peptide, sermorelin has a very short half-life but is highly potent at low doses.
How Do Ipamorelin And Sermorelin Differ in Their Functions?
The primary functional difference lies in their receptor targets and subsequent downstream effects:
Receptor Binding
- Ipamorelin binds to the ghrelin receptor (also known as GHSR-1a).
This receptor is located on somatotroph cells of the pituitary gland, and its activation leads
directly to growth hormone release.
- Sermorelin binds to GHRH receptors situated on the same somatotroph cells.
The stimulation triggers a cascade that involves cyclic AMP production and ultimately results in growth
hormone secretion.
Hormonal Profile
- Ipamorelin’s selective action means it largely leaves other pituitary hormones untouched.
Users often report minimal increases in prolactin or cortisol, which can be
advantageous for maintaining hormonal balance.
- Sermorelin, while also relatively selective, may cause a modest
rise in insulin-like growth factor 1 (IGF-1) levels due to its effect on the liver and other tissues.
Because it is a true GHRH analogue, it mimics the natural pulsatile release pattern of growth hormone more
closely.
Onset and Duration
- Ipamorelin has a very rapid onset; peak effects can be seen within 15–30 minutes after injection. Its half-life is short, around 30–45 minutes, but its potency allows
for low dosing.
- Sermorelin’s onset is slightly slower, with maximal stimulation occurring roughly 60–90 minutes post-injection. It has a similar short half-life
of about 10–15 minutes, yet because it acts upstream in the hormonal cascade, its
effects can last longer as growth hormone remains elevated for several
hours.
Clinical Uses
- Ipamorelin is frequently used for anti-aging protocols,
muscle building, and recovery from injury. Its minimal impact
on other hormones makes it suitable for long-term use.
- Sermorelin is often chosen for diagnosing growth hormone deficiency (as part of
a GH stimulation test) or for short-term therapeutic interventions
in children and adults with proven deficiencies.
Side Effect Profile
- Ipamorelin can cause mild water retention, increased appetite, or tingling at
the injection site. Because it does not significantly elevate prolactin, sexual side effects are rare.
- Sermorelin may produce transient increases in blood sugar, a slight rise in heart rate, and occasional headaches.
Some users note a « brain fog » effect if taken too close to bedtime.
Cost and Availability
- Ipamorelin is typically more expensive per dose than sermorelin due to its synthesis complexity.
However, because the effective dose is very small (often 100–200 micrograms), overall costs can be comparable.
- Sermorelin is relatively inexpensive but requires frequent dosing
for maximal benefit, which may add up over time.
In summary, while both peptides stimulate growth hormone
release, ipamorelin does so via ghrelin receptor activation with
minimal collateral hormonal effects, whereas sermorelin mimics the natural
GHRH pathway and promotes a more physiological pulse of
growth hormone. Combining them can amplify overall hormone output and
provide a broader range of benefits, but careful attention to dosing schedules, potential side effects, and
individual health goals is essential for safe and effective use.
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